Informatie over wetenschappelijk onderzoek door het EPZM

Daisy JanssenDaisy Janssen, coördinator onderzoek van het Expertisecentrum Palliatieve Zorg Maastricht wint ‘Joint Second Prize in the EAPC Early Researcher Award’

Het expertisecentrum palliatieve zorg van het MUMC+ heeft drie onderzoekslijnen: pijn, dyspneu en advance care
planning. 
Beide symptomen komen zeer frequent voor bij diverse groepen chronisch zieken en hebben grote consequenties voor de kwaliteit van leven. De onderzoekslijn ‘Pijn’ zal met name focussen op de behandeling van oncologische pijn. De onderzoekslijn ‘Dyspnoe’ legt de nadruk op dyspnoe-management bij patiënten met niet-oncologische aandoeningen, zoals chronisch orgaanfalen, en advance care planning bij patiënten met een levensbedreigende chronische aandoening, zoals COPD en hartfalen. De focus bij advance care planning ligt op wilsonbekwame patiënten, zoals mensen met een verstandelijke beperking of dementie.

Publicaties

2019
Liesbeth de Boer-Beskers, dialyseverpleegkundige. M.m.v. dr. E. Litjens, internist-nefroloog; Patricia Savelberg, dialyseverpleegkundige; Sonja Mulder, dialyseverpleegkundige; Marion Simons-de Haas, dialyseverpleegkundige; Anouk Geurts, dialyseverpleegkundige; Joke Leone-Jacobs, dialyseverpleegkundige; Paul Oyen, consulent palliatieve zorg; dr. A. Courtens, coördinator Expertisecentrum palliatieve zorg. Allen werkzaam in het MUMC+. Palliatieve zorg op de afdeling dialyse van het MUMC+. Dialyse & Nefrologie magazine (mag#3_2019_14-17)
 
H. Voss, A. Vogel, A. M. A. Wagemans, A. L. Francke, J. F. M. Metsemakers, A. M. Courtens & A. J. E. de Veer. Advance care planning in the palliative phase of people with intellectual disabilities: analysis of medical files and interviews. Journal of Intellectual Disability Research (JIDR),doi: 10.1111/jir.12664
 
Janssen DJ, Boyne J, Currow DC, Schols JM, Johnson MJ, La Rocca HB.Timely recognition of palliative care needs of patients with advanced chronic heart failure: a pilot study of a Dutch translation of the Needs Assessment Tool: Progressive Disease - Heart Failure (NAT:PD-HF). Eur J Cardiovasc Nurs. 2019 Feb 13
 
2018
Carmen H.M. Houben, Martijn A. Spruit, Hans Luyten, Herman Jan Pennings, Vivian E.M. Van Den Boogaart, Jacques P.H.M. Creemers, Geertjan Wesseling, Emiel F.M. Wouters, Daisy J.A. Janssen. Cluster-randomised trial of a nurse-led advance care planning session in patients with COPD and their loved ones. Thorax. https://doi.org/10.1136/thoraxjnl-2018-211943
 
Martens MJM, Janssen DJA, Schols JMGA, Beuken van den - Everdingen van MHJ. Opioid Prescribing Behavior in Long-Term Geriatric Care in the Netherlands. JAMDA. 2018;(11):974-80
 
van den Beuken-van Everdingen, M.H.J., van Kuijk, S.M.J., Janssen D.J.A., and Joosten, E.A.J. Treatment of pain in cancer: towards personalised medicine. Cancers. 2018. 10 (12). 10(502) (IF 5.326)

J. Haumann, S.M.J. van Kuijk, E. A. Joosten, M.H.J. van den Beuken-van Everdingen. The association between patient characteristics and opioid treatment response in      neuropathic and nociceptive pain due to cancer. Journal of Palliative Medicine 2018; (IF 2.490)

Cindy A. Verberkt, Marieke H.J. van den Beuken-van Everdingen, Jos M.G.A. Schols, Sushma Datla, Carmen D. Dirksen, Miriam J. Johnson, Sander M.J. van Kuijk, Emiel F.M. Wouters, Daisy J.A. Janssen. Adverse respiratory effects of opioids for      chronic breathlessness: to what extend can we learn lessons from chronic pain? Eur Respir J 2018;52(1):1800882 (IF 12.242) 

Johan Haumann, Sander M.J. van Kuijk, José W. Geurts, Frank J.P. Hoebers, Bernd Kremer, Elbert A. Joosten, Marieke H.J. van den Beuken-van Everdingen. Methadone versus Fentanyl in Patients with Radiation Induced Nociceptive Pain with Head and Neck Cancer, a randomized controlled non-inferiority trial. Pain Practice 2018;18(3):331-40  (IF 2.495)

Robert Janknegt, Marieke van den Beuken – van Everdingen, Sjouke Schiere, Michael Überall, Roger Knaggs, Jaquie Hanley, Morten Thronaes. Rapid acting fentanyl formulations in breakthrough pain in cancer. Drug selection by means of the System of Objectified Judgement Analysis. Eur J Hosp Pharm 2018;25:e2 (IF 0.538)

Vaes, A.W., Delbressine, J.M.L., Mesquita, R., Goertz, Y.M.J., Janssen, D.J.A. Nakken, N., Franssen, F.M.E., Vanfleteren, L.E.G.W., Wouters, E.F.M. and Spruit M.A. The impact of pulmonary rehabilitation on activities of daily living in patients with COPD. J Appl Physiol. 2018. Published online ahead of print.

Van Herck, M., Spruit, M.A., Burtin, C., Djamin, R., Antons, J., Goertz, Y.M.J., Ebadi, Z., Janssen, D.J.A., Vercoulen, J.H., Peters, J.B., Thong, M.S.Y., Prins, J.B., Otker, J., Coors, A., Sprangers, M.A.G., Muris, J.W.M., Wouters, E.F.M., and van ’t Hul, A. Fatigue is highly prevalent in patients with asthma and contributes to the burden of disease. J Clin Med. 2018. 7(12):471.

van Beers, M., Janssen, D.J.A., Gosker, H.R., and Schols A.M.W.J. Cognitive impairment in COPD: disease burden, determinants and possible future interventions. Exp Rev Resp Med. 2018. 1-14.

Houben-Wilke, S., Janssen, D.J.A., Franssen, F.M.E., Vanfleteren, L.E.G.W., Wouters E.F.M., and Spruit, M.A. Contribution of individual COPD Assessment Test (CAT) items to CAT total score and effects of pulmonary rehabilitation on CAT scores. Health Qual Life Outcomes. 2018. 16(1):205.

Nakken, N., Spruit, M.A., van den Bogaart, E.H.A., Crutzen, R., Muris, J.W., Wouters, E.F.M., Janssen, D.J.A. Identifying causes of perceptual differences in problematic activities of daily life between patients with COPD and proxies: a qualitative study. Aust Occup Ther J. 2018.

Goërtz, Y.M.J., Looijmans, M.,  Prins, J.B., Janssen, D.J.A., Thong, M.S.Y.,Peters, J.B., Burtin, C., Meertens-Kerris, Y., Coors, A., Muris, J.W.M., Sprangers, M.A.G., Wouters, E.F.M.,  Vercoulen, J.H., and Spruit M.A. Fatigue in patients with Chronic Obstructive Pulmonary Disease: protocol of the longitudinal, observational FAntasTIGUE study. BMJ Open. 2018;8:e021745.

Janssen, D.J.A., Johnson, M.J., Spruit M.A. Palliative care needs assessment in chronic heart failure. Curr Opin Support Palliat Care. 2018. 12:25-31.

Jabbarian, L.J., Zwakman M., van der Heide, A., Kars M.C., Janssen, D.J.A., van Delden, J.J.M., Rietjens, J.A.C., Korfage I.J. Advance care planning in chronic respiratory diseases: a systematic review of preferences and practices. Thorax. 2018. 73(3):222-230.

Cleutjens, F.A.H.M., Spruit, M.A., Ponds, R.W.H.M., Vanfleteren, L.E.G.W., Franssen, F.M.E., Gijsen C., Dijkstra, J.B., Wouters, E.F.M., and Janssen D.J.A. Cognitive impairment and clinical characteristics in patients with COPD. Chron Resp Dis. 2018.15(2):91-102.

M.P.H. Bischoff, prof. dr. M.H.J. van den Beuken-Everdingen, prof. dr. A-M.C. Dingemans. Effect of early and systematic integration of palliative care in patients with advanced cancer: a randomised controlled trial. van Butsele et all. NTvO 2018;15(6):236-7 Susanto C, Kooman J, Courtens AM, Konings CJAM. Conservative care as a treatment option for patients aged 75 years and older with CKD stage V: a National survey in the Netherlands.Eur Geriatr Med. 2018;9(2):235-242. doi: 10.1007/s41999-018-0031-9. Epub 2018 Feb 12

2017
Rietjens JAC, Sudore RL, Connolly M, van Delden JJ, Drickamer MA, Droger M, van der Heide A, Heyland DK, Houttekier D, Janssen DJA, Orsi L, Payne S, Seymour J, Jox RJ, Korfage IJ, on behalf of the European Association for Palliative Care. Definition and recommendations for advance care planning: an international consensus supported by the European Association for Palliative Care. Lancet Oncol. 2017;18:e543-51

2016
J. Haumann, J.W Geurts, S.M.J. van Kuijk, B. Kremer, E.A. Joosten, M.H.J. van den Beuken-van Everdingen. Methadone is superior to fentanyl in treating neuropathic pain in patients with head-and-neck cancer. Eur J Cancer. 2016;65:121-129

Hochstenbach LM, Zwakhalen SM, Courtens AM, van Kleef M, de Witte LP. Feasibility of a mobile and web-based intervention to support self-management in outpatients with cancer pain. Eur J Oncol Nurs. 2016;23:97-105

Van den Heuvel LA, Spruit MA, Schols JM, Hoving C, Wouters EF, Janssen DJ. Barriers and facilitators to end-of-life communication in advanced chronic organ failure. Int J Palliat Nurs. 2016;22(5):222-9

C.A. Verberkt, M.H.J. van den Beuken-van Everdingen, F.M.E. Franssen, C.D. Dirksen, J.M.G.A. Schols, E.F.M. Wouters, D.J.A. Janssen. A randomized controlled trial on the benefits and respiratory adverse effects of morphine on refractory dyspnea in patients with COPD: protocol of the MORDYC study. Contemporary Clinical Trials. 2016;47:228-34

Marieke H.J. van den Beuken-van Everdingen, MD, PhD,  Laura M.J. Hochstenbach, MSc, Bert E.A.J. Joosten, PhD, Vivianne C.G. Tjan-Heijnen, MD, PhD, Daisy J.A. Janssen, MD, PhD. Update on prevalence of pain in patients with cancer: Systematic review and meta-analysis. J Pain Symptom Management. 2016;51(6):1070-90

Marieke HJ van den Beuken-van Everdingen, MD, PhD, Alexander de Graeff, MD, PhD,Joost LM Jongen, MD, PhD,Denise  Dijkstra, MsC, Irina Mostovaya, MD, PhD, Kris C Vissers, MD, PhD, on behalf of the working group national guideline “Diagnosis and treatment of cancer pain”. Pharmacological treatment of pain in cancer patients: the role of adjuvant analgesics, a systematic review. Pain Practice. 2016

Hendriks LE, Hermans BCM, van den Beuken-van Everdingen MHJ, Hochstenbag MM, Dingemans A-M. Effect of bisphosphonates, denosumab and radioisotopes on bone pain and quality of life in non-small cell lung cancer patients with bone metastases: a systematic review. Journal of Thoracic Oncology. 2016;11(2):155-73

2015
Wagemans AMA, van Schrojenstein Lantman-de Valk HMJ, Proot IM, Metsemakers J, Tuffrey-Wijne I, Curfs LMG. End-of-Life Decision-Making for People With Intellectual Disability From the Perspective of Nurses. Journal of Policy and Practice in Intellectual Disabilities. 2015;12(4):294-302

G. (Art) Vreugdenhil en M.H.J. (Marieke) van den Beuken-van Everdingen. Starten en stoppen met palliatieve tumorbehandeling, Overwegingen in het kader van kwaliteit van leven en kosten. Nederlands Tijdschrift voor Geneeskunde. 2015;159:A8729

Loes M.T. Hoogveld, Dennis C.J.J. Bergmans, Sergej de Vries, Huub van Proemeren, Marieke H.J. van den Beuken-van Everdingen, Jan G. Zijlstra, Walther N.K.A. van Mook IC-patiënten die thuis willen overlijden. Hoe kun je deze laatste wens vervullen? Nederlands Tijdschrift voor Geneeskunde. 2015;159: A8711:1-5 

Daisy J.A. Janssen, Marieke H.J. van den Beuken-van Everdingen en Jos M.G.A. Schols Verrast door de ‘surprise question’ Nederlands Tijdschrift voor Geneeskunde. 2015;159(17):730-3

Hochstenbach LMJ, Courtens AM, Zwakhalen SMG, Kleef van M, Witte de LP. Self-management support intervention to control cancer pain in the outpatient setting: a randomized controlled trial study protocol. BMC Cancer. 2015;416(15). doi:10.1186/s12885-015-1428-1 

Magdelijns FJH, Beuken van den-Everdingen van MHJ, Courtens AM, Janssen DJA. Behandeling van doorbraakpijn bij kanker. Ned Tijdschr Geneeskd. 2015;159:A8121

2014
Wagemans AMA, Wijmen FCB. Advance care planning: Proactief medisch beleid bij mensen met een verstandelijke beperking.Ned Tijschr Geneeskd. 2014; 158:A8433

Vermeulen J, Verwey R, Hochstenbach LMJ, Weegen van der S, Man YP, Witte de LP. Experiences of multidisciplinary development team members during user-centered design of telecare products and services: A qualitative study. Journal of Medical Internet Research. 2014;16(5):e124.

Janssen DJA, McCormick JR. Palliative care and pulmonary rehabilitation. Clin Chest Med. 2014. doi:10.1016/j.ccm.2014.02.006

Houben CH, Spruit MA, Groenen M., Wouters EFM, Janssen DJA. Efficacy of Advance Care Planning: A systematic review and meta-analysis. J Am Med Dir Assoc.  doi.org/10.1016/j.jamda.2014.01.008

2013
Houben CHM, Spruit MA, Wouters EFM, et al. A randomised controlled trial on the efficacy of advance care planning on the quality of end-of-life care and communication in patients with COPD: the research protocol. BMJ Open. 2014;4:e004465. doi:10.1136/bmjopen-2013-00446

Beuken van den-Everdingen van MHJ, Geurts JW, Patijn J. Prolonged QT interval by methadone: Relevance for daily practice? A prospective study in patients with cancer and noncancer pain. J Opioid Manag. 2013;9(4): 263-267