Informatie over wetenschappelijk onderzoek door het EPZM
Het Expertisecentrum Palliatieve Zorg van het MUMC+ doet op verschillende terreinen onderzoek.
Voor een overzicht van lopend en afgesloten onderzoek zie onderstaande posters en verdere informatie per onderzoek hieronder.
Jubileum Symposium Expertisecentra Palliatieve Zorg Nederland
Posters EPZ-M
Bijgaande posters werden door het EPZ-M opgesteld i.v.m. het EPZ-jubileum symposium dat op 25 november 2025 plaats vindt in het UMC Utrecht.
12,5 jaar Expertisecentra Palliatieve Zorg Nederland
Blik naar de toekomst, blik naar voren.
Onderwijs en onderzoek voor passende zorg in de palliatieve fase.
Zie HIER voor de pdf van de poster.
Lopend onderzoek
Methadon studie
Methadon als toegevoegde pijnstiller bij kankergerelateerde botpijn: een dubbel-blinde gerandomiseerde studie in meerdere ziekenhuizen (MetAddon).
OPTIMISM
Ontwikkeling en implementatie van structurele symptoom monitoring voor patiënten met ongeneeslijke kanker.
Onderzoek naar vitamine B1 tekort bij patiënten met een delier
In dit onderzoek wordt bekeken of er een verband is tussen het voorkomen van een delier en de vitamine B1 waarde in het bloed.
Het SPING blok
Palliatieve pijnbehandeling voor kwetsbare ouderen met heupfractuur
Lavender studie
Onderzoek naar de problemen van patiënten met longkanker die lang overleven en hun naasten
Levend ontslag uit hospice
Symptoom monitoring SEH met USD-4D - vervolg
Afgerond onderzoek
COMPASSION
Passende palliatieve zorg voor patienten met COPD in het MUMC+: een complexe uitdaging
Lees hieronder de rapportage met o.a. overwegingen en aanbevelingen - januari 2026
Droge Mond Studie
Een onderzoek naar het effect van pilocarpine druppels, lokaal aangebracht in de mond, op de klacht “droge mond”.
Verder onderzoek waarbij we betrokken zijn (geweest)
-
I-HARP
-
Kunnen de klachten van xerostomie bij oudere patiënten behandeld worden met pil…
-
Proactieve en geestelijke zorg voor kwetsbare ouderen in de huisartsenpraktijk
-
Waarom gebruiken patiënten die behandeld worden voor kanker cannabis: wat zijn …
-
Zorgervaring en stress bij chronisch zieken in tijden van corona
Publicaties
-
2026
Moyke A.J. Versluis, Froukje E. de Vries, Yvette M. van der Linden, Marianne Kool, Jarmo C.B. Hunting, Hanneke W.M. van Laarhoven, Arnold Baars, Sander M. de Hosson, Wouter de K. Jong, Mathijs P. Hendriks, Marieke H.J. van den Beuken- van Everdingen, Tineke J. Smilde, Magdolen Youssef-El Soud, Marjolein H. Tilkema-Tiebosch, Dirkje Sommeijer, Alexander de Graeff, Caroline Mandigers, Lia van Zuylen, Art Vreugdenhil, Annemieke van der Padt-Pruijsten, Evelien J.M. Kuip, Lobke van Leeuwen-Snoeks, Lonneke V. van de Poll-Franse, Natasja J.H. Raijmakers. Death anxiety during the last year of life in patients with advanced cancer: longitudinal results from the eQuiPe study. Psycho-oncology 2026 (IF 3.5) https://doi.org/10.1002/pon.70429
Van der Meulen, Annelot; Stoppelenburg, Arianne; Theunissen, Maurice; De Nijs, Ellen; van den Beuken-van Everdingen, Marieke; van der Linden, Yvette. Dry mouth in palliative care: a systematic review of clinical practice guidelines around the world. Palliative Medicine 2026 accepted (IF 3.9)
Miriam van der Velden, Nick Visschers, Miriam Faes, Bart Spaetgens, Eline Brundel, Marieke van den Beuken-van Everdingen, Arnela Suman. Beyond Pain Relief: A Thematic Exploration of Informal Caregiver Experiences and Needs Following SPING Block Treatment in Geriatric Hip Fracture Patients. European Geriatric Medicine accepted 2026 (IF 3.6) doi.org/10.1007/s41999-026-01432-y
Annette WG van der Velden, Albert H de Heij, Marieke HJ van den Beuken, Evelien JM Kuip, Ginette M Hesselmann, Ellen JM de Nijs, MR Rosy El Aissati-Caldwell, Astrid W Oosten, Anna KL Reyners, Pauline de Graeff. Identification of patients with a limited life expectancy and the involvement of palliative care teams in Dutch hospitalized patients: a flash mob study. BMC Palliative Care….accepted 2026 (2.5)
Moyke A.J. Versluis, Yvette M. van der Linden, Lobke van Leeuwen-Snoeks, Marieke H.J. van den Beuken- van Everdingen, Mathijs P. Hendriks, Ben E.E.M. van den Borne, Dirkje Sommeijer, Jean-Paul A. van Basten, Annemieke van der Padt-Pruijsten, Alexander de Graeff, Jarmo C.B. Hunting, Evelien J.M. Kuip, Anne S.R. van Lindert, Maggy Youssef-El Soud, Martine F. Thijs-Visser, Art Vreugdenhil, Hanneke W.M. van Laarhoven, Wouter K. de Jong, Caroline Mandigers, Lia van Zuylen, Jeroen kloover, Tineke J. Smilde, Lonneke V. van de Poll-Franse & Natasja J.H. Raijmakers. Patients’ and relatives’ perspectives on the quality of end-of-Life care in advanced cancer: from the final months to bereavement. PLOS Medicine 2026;feb 9:1-17 (IF 15.8) doi.org/10.1371/journal.pone.0342068
Posters
Christina A.M. de Laat, Helen P.A. Driessen, Ida J. Korfage, An K. L. Reyners, Marieke H. J. van den Beuken-van Everdingen, Marien O. den Boer, Geert-Jan Creemers, Alexander de Graeff, Mathijs P. Hendriks, Jarmo C. B. Hunting, Wouter K. de Jong, Evelien J. M. Kuip, Hanneke W. M. van Laarhoven, Lobke van Leeuwen, Anne S. R. van Linder, Caroline M. P. W. Mandigers, Peter Nieboer, Annemieke van der Padt-Pruijsten, Tineke J. Smilde, Dirkje W. Sommeijer, Martine F. Thijs, Marian A. Tiemessen, Allert H. Vos, Art Vreugdenhil, Philo T. Werner, Lia van Zuylen, Lonneke V. van de Poll-Franse, Natasja J. H. Raijmakers, on behalf of the eQuiPe study group. Involvement in proactive care planning in the last year of life of patients with metastatic cancer: longitudinal results from the eQuiPe study. Nederlands-Vlaamse Wetenschapsdagen 9-10 Oct 2025, Houten
Moyke A.J. Versluis, Yvette M. van der Linden, Lobke van Leeuwen-Snoeks, Marieke H.J. van den Beuken- van Everdingen, Mathijs P. Hendriks, Ben E.E.M. van den Borne, Dirkje Sommeijer, Jean-Paul A. van Basten, Annemieke van der Padt-Pruijsten, Alexander de Graeff, Jarmo C.B. Hunting, Evelien J.M. Kuip, Anne S.R. van Lindert, Maggy Youssef-El Soud, Martine F. Thijs-Visser, Art Vreugdenhil, Hanneke W.M. van Laarhoven, Wouter K. de Jong, Caroline Mandigers, Lia van Zuylen, Jeroen kloover, Tineke J. Smilde, Lonneke V. van de Poll-Franse & Natasja J.H. Raijmakers. Quality of end-of-life care through the eyes of patients and loved ones: the importance of continuity and next-of-kin care getting. Nederlands-Vlaamse Wetenschapsdagen 9-10 Oct 2025, Houten
L. Ham, D. Seelen , M.H.J. van den Beuken - van Everdingen , A.W.G. van der Velden , G.M. Hesselmann , A.F.Q. Dijxhoorn , A. van der Scheer , C.H. Stoop , C.M. Cramer - van der Welle. Measuring quality of palliative care in the Netherlands: set of 17 indicators. EAPC Helsinki 29-31 May 2025
A.I. v.d. Meulen, A. Stoppelenburg, E.J.M. de Nijs, B.J.E.G. Coenegracht, M. Theunissen, Y.M. v.d. Linden, M.H.J. Beuken – van den Everdingen. Dry mouth at the end of life: a systematic review of clinical practice guidelines world-wide. EAPC Helsinki 29-31 May 2025
2025
Morena Shkodra, Amaia Urrizola, Marie Fallon, Per Sjøgren, Marieke van den Beuken-van Everdingen, Katarina Hagen, Marianne Jensen Hjermstad, Tonje Lundeby, Stein Kaasa, Augusto Caraceni on behalf of the MyPath consortium. The MyPath Pain Pathway: developing a digital patient-centred care pathway for cancer pain. JPSM 2025;70(6):592-601 (IF 3.5)
Maurice Theunissen, Sacha Lardenoye, Marieke H.J. van den Beuken-van Everdingen & Patricia M. Stassen. The surprise question: predictive accuracy in an unselected emergency department population - a prospective study in nurse and physisians. Annals of Medicine 2025, VOL.57, NO 1, 2529575
Miriam WA van der Velden, Miriam C Faes, Frank PJF de Loos, Niels Berende, Marieke MHJ van den Beuken-van Everdingen, Arnela Suman. “SPING Block Analgesia in Non-Operative Proximal Femur Fracture Management in Frail Older Adults: A Retrospective Cohort Study. Geriatrics 2025;10(1):1-14 (IF 2.1) doi.org/10.3390/geriatrics10010010
D. Bastings, T. Schermer, C. Tromp, B. Vriens, Dr. T.J Smilde, M.P. Hendriks, J van Roij , Dr. C. Mandigers, Prof. dr. M.H.J. van den Beuken – Everdingen, Dr. D.W. Sommeijer, Prof. Dr. H.W.M. van Laarhoven, Dr. N.J.H., Raijmakers. Supportive care needs in patients with advanced cancer who experience psychological problems, and their associated characteristics: a multicentre observational cohort study (eQuiPe study). J of Palliative Medicine 2025;28(5):571-579 (IF 2.8)
2024
Wetenschappelijke publicaties
Andrew Davies, Norah Fagan, Jenny Power and Amy Taylor met medewerking van o.a. Marieke H.J. van den Beuken. ‘Constipation’: One word, many meanings amongst persons with cancer: An observational study.
Maike S Imkamp, Maurice Theunissen, Sander M van Kuijk, Johan Haumann, Oscar Corli, Cristina Bosetti, Wojciech Leppert , Cinzia Brunelli, Ernesto Zecca, Marieke H van den Beuken-van Everdingen . Finding predictors for successful opioid response in cancer patients: An analysis of data from four randomized controlled trials. Pain Practice 2024;24:101-108.
Julia MM Deuss, Mandy MM Jansen, Monique CT Bongaerts, Maurice Theunissen and Marieke HJ van den Beuken-van Everdingen. A Retrospective Longitudinal Cohort Study: The Effect of Long-Term Use of Methadone and Associated Factors on QTc in a Maintenance Program. Clinmed DOI: 10.23937/2474-3631/1510038
Jeroen R J H Gruiskens, Liesbeth F M van Hoef, Maurice M Theunissen, Annemie M Courtens, Annerika H M Gidding-Slok, Onno C P van Schayck, Marieke M H J van den Beuken-van Everdingen . Recommadations for Improving Chronic Care in Times of a Pandemic Based on Patient Experiences. J Am Med Dir Assoc. 2024 Apr;25(4):623-632.e5.doi: 10.1016/j.jamda.2023.10.013. Epub 2023 Nov 22.Maike S.V. Imkamp BSc a c, Maurice Theunissen PhD a, Wolfgang Viechtbauer PhD b, Sander M.J. van Kuijk PhD c, Marieke H.J. van den Beuken – van Everdingen MD, PhD a. Shifting Views on Cancer Pain Management: A Systematic Review and Network Meta-Analysis. JPSM, 4 juni 2024. https://doi.org/10.1016/j.jpainsymman.2024.05.022
Daniël C.M. Huijten, Laura Hofstede, Sami O. Simons, Stephanie C.M. Ament, Nicolette Gunnink-Boonstra, Marieke H.J. van den Beuken-van Everdingen, Daisy J.A. Janssen. Development of the conversation tool “I-HARP for COPD” for early identification of palliative care needs in patients with chronic obstructive pulmonary disease. Published online by Cambridge University Press: 16 February 2024
Chantal F R Pereira, Anne-Floor Q Dijxhoorn, Berdine Koekoek, Monique van den Broek, Karin van der Steen, Marijanne Engel, Marjon van Rijn, Judith M Meijers, Jeroen Hasselaar, Agnes van der Heide, Bregje D Onwuteaka-Philipsen, Marieke H J van den Beuken-van Everdingen, Yvette M van der Linden, Manon S Boddaert, Patrick P T Jeurissen, Matthias A W Merkx, Natasja J H Raijmakers. Potentially inappropriate end of life care and healthcare costs in the last 30 days of life in regions providing integrated palliative care in the Netherlands: a registration-based study. International Journal of Integrated Care DOI: 10.5334/ijic.7504
Rapportage
2023
Rolf A.H. Snijders, Linda Brom, Maurice Theunissen, Marieke H.J. van den Beuken-van Everdingen. Update on Prevalence of Pain in Patients With Cancer a Systematic Literature Review and Meta-Analysis.
Cancers 2023, 15(3), 591; https://doi.org/10.3390/cancers15030591Jeroen R.J.H. Gruiskens, Liesbeth van Hoef, Maurice Theunissen, Annemie M. Courtens, Marieke M.H.J. van den Beuken – van Everdingen, Annerika H.M. Gidding-Slok, Onno C.P. van Schayck. The psychosocial impact of the COVID-19 pandemic on chronic care patients. DOI:10.1016/j.jamda.2023.01.003
Posters
E-StOIC study: single question versus Rome IV diagnostic criteria for diagnosis of opioid-induced constipation
Prof Andrew Davies, Dr Wendy Oldenmenger, Prof Marieke van den Beuken –van Everdingen, Dr Craig Gouldthorpe1, Norah FaganE-StOIC study: prescribed and non-prescribed management of OIC
Prof Andrew Davies, Dr Wendy Oldenmenger, Prof Marieke van den Beuken –van Everdingen, Dr Craig Gouldthorpe1, Norah Fagan2022
Verberkt Cornelia, van den Beuken-van Everdingen Marieke, Schols Jos, Wouters Emiel, Janssen Daisy. Morphine for chronic breathlessness in COPD: improvement predictors—cross-sectional study. BMJ Supportive and Palliative Care 2022 doi.org/ 10. 1136/ spcare- 2022-003693) (IF 3.568)
S. Lardenoye, M. Theunissen, A. N.A. van der Horst-Schrivers, M.H.J. van den Beuken-van Everdingen. A missed opportunity in the ED: Palliative care. American Journal of Emergency Medicine 2022;58:345-346 doi.org/10.1016/j.ajem.2022.04.014 (IF 2.469)
Y. Oelen, S. Revenberg, J. de Vos-Geelen, R. van Geel, J. Schoenmaekers, M. van den Beuken-Everdingen, L.B.J. Valkenburg-van Iersel. Cannabinoid consumption among cancer patients receiving systemic anti-cancer treatment in the Netherlands. J Cancer Research and Clinical Oncology 2022;31(5): https://doi.org/10.1007/s00432-022-04085-z (IF 4.553)
H.H. Stoorvogel, J.C.M. van Haastregt, M. Theunissen, J.J.A.O. Schoenmaekers, A. Hoeben, M.H.J. van den Beuken-van Everdingen. Unacceptable pain in oncology: the patients’ perspective on reasons for absence of pain interventions. European Journal of Cancer Care 2022;31(5):e13628 http://doi.org/10.1111/ecc.13628 (IF 2.520)
Maurice Theunissen, Fabienne Magdelijns, Daisy J.A. Janssen, Myrthe W. Naaktgeboren, Annemie Courtens, Sander MJ van Kuijk, Marieke van den Beuken-van Everdingen. The Surprise Question in older hospitalized patients; to use or not to use? JAMDA 2022;23(5):894–896 (IF 4.669) doi.org/10.1016/j.jamda.2022.01.058
Annelieke Damen, Natasja J.H. Raijmakers, Janneke van Roij, Anja Visser, Marieke van den Beuken-Everdingen, Eveline Kuip, Hanneke W.M. van Laarhoven, Lobke van Leeuwen-Snoeks, Annemieke van der Padt-Pruijsten, Carmen Schuhmann, Tineke J. Smilde, Carlo Leget, George Fitchett. Spiritual well-being and associated factors in Dutch patients with advanced cancer. J Pain Sympt Manage 2022 Mar;63(3):404-414 (IF 3.077)
Janneke van Roij, Natasja Raijmakers, Laurien Ham, Marieke van den Beuken-van Everdingen et all. Quality of life and quality of care as experienced by patients with advanced cancer and their relatives: a multicenter observational cohort study (eQuiPe) . European Journal of Cancer 2022;165:125-135 (IF 9.162) doi.org/10.1016/j.ejca.2022.01.039
Andrew Davies, Saverio Cinieri, Denis Dupoiron, Sofia España Fernandez, Johan Leclerc, Vincenzo Montesarchio, Kyriaki Mystakidou, Judith Serna, Jan Tack, on behalf of the NACASY Study Group. A Prospective, Real-World, Multinational Study of Naloxegol for Patients with Cancer Pain Diagnosed with Opioid-Induced Constipation—The NACASY Study. Cancers 2022;14(5):1128 (IF 6.639) doi.org/10.3390/cancers14051128
Stephanie MC Ament, Lisette M van den Broek, Marieke HJ van den Beuken-van Everdingen, Josiane JJ Boyne, José MC Maessen, Bas C Bekkers, Louise Bellersen, Hans-Peter Brunner-La Rocca, Yvonne Engels, Daisy JA Janssen. What to consider when implementing a tool for timely recognition of palliative care needs in heart failure: a context-based qualitative study. BMC Palliative Care 2022;21:1-9 doi.org/10.1186/s12904-021-00896-y (IF 2.93)
Posters
Maurice Theunissen, Fabienne Magdelijns, Daisy J.A. Janssen, Myrthe W. Naaktgeboren, Annemie Courtens, Sander MJ van Kuijk, Marieke van den Beuken-van Everdingen. The Surprise Question in older hospitalized patients; to use or not to use? 12th World Congress of the EAPC 18 -20 May 2022
M. H. van den Beuken-van Everdingen1, S. van Kuijk, M. Theunissen, M. Imkamp, J. Haumann, C. Brunelli, W. Leppert, C. Bosetti, O. Corli. Effectivity of 5 different strong opioids in the treatment of pain in oncology. 12th World Congress of the EAPC 18 -20 May 2022
Maurice Theunissen, Fabienne J.H. Magdelijns, Daisy J.A. Janssen, Myrthe W. Naaktgeboren, Annemie Courtens, Sander M.J. van Kuijk, Marieke van den Beuken-van Everdingen. The Surprise Question in older hospitalized patients; to use or not to use? Dutch-Flemish palliative research days 31 March- 1 April 2022
M. Imkamp, M. Theunissen, S.M.J. van Kuijk, J. Haumann, M.H.J. van den Beuken - van Everdingen. Effectiviteit van 5 verschillende opioïden voor de behandeling van oncologische pijn: een predictiemodel op basis van geaggregeerde data. Dutch-Flemish palliative research days 31 March- 1 April 2022
B.D.C. Pouwels, S.O. Simons, M. Theunissen, M.L. Peters, J.J.A.O. Schoenmaekers, S.C.A.M. Bekkers, M.H.J. van den Beuken-van Everdingen. Health care use during COVID-19 and the effect on psychological distress in patients with chronic cardiopulmonary disorders in the Netherlands. Dutch-Flemish palliative research days 31 March- 1 April 2022
2021
Aniek Anna Julia Martine Willems MSc, Aliaksandr Fedorovich Kudrashou MD, PhD, Maurice Theunissen PhD, Ann Hoeben MD, PhD, Marieke Henrica Johanna Van den Beuken – Van
Everdingen MD, PhD. Measuring pain in oncology outpatients: Numeric Rating Scale versus acceptable/non acceptable pain. A prospective single center study.B.D.C. Pouwels, S.O. Simons, M. Theunissen, M.L. Peters, J.J. Schoenmaekers, S.C. Bekkers, M.H.J. van den Beuken-van Everdingen. Healthcare use during COVID-19 and the effect on psychological distress in patients with chronic cardiopulmonary disorders in the Netherlands: a cross- sectional study. BMJ Open 2021;11:e046883.
Hille Voss, Anique G.F.M. Vogel, Annemieke M.A. Wagemans, Anneke L. Francke,
Job F.M. Metsemakers, Annemie M. Courtens, and Anke J.E. de Veer. Development, Implementation, and Evaluation of an Advance Care Planning Program for Professionals in Palliative Care of People With Intellectual Disability. Intellectual and developmental disabilities (AAIDD), 2021, Vol. 59, No. 1, 39–542020
Courtens Annemie, Giel Vaessen, Annette Bour. Palliatieve zorg in het onderwijs. TVZ 02/20
2019
Beuken-van Everdingen MHJ van den, M.A.E. de van der Schueren. Nutrition and Palliative Care Chapter: What about food when there are no more therapeutic options for the bladder cancer? In: Diet and fighting bladder cancer, Maurice Zeegers 2019
Boer-Beskers Liesbeth de, dialyseverpleegkundige. M.m.v. dr. E. Litjens, internist-nefroloog; Patricia Savelberg, dialyseverpleegkundige; Sonja Mulder, dialyseverpleegkundige; Marion Simons-de Haas, dialyseverpleegkundige; Anouk Geurts, dialyseverpleegkundige; Joke Leone-Jacobs, dialyseverpleegkundige; Paul Oyen, consulent palliatieve zorg; dr. A. Courtens, coördinator Expertisecentrum palliatieve zorg. Allen werkzaam in het MUMC+. Palliatieve zorg op de afdeling dialyse van het MUMC+. Dialyse & Nefrologie magazine (mag#3_2019_14-17)
Courtens A, G. Vaessen, A. Bour, A. van Pol, M. van den Beuken–van Everdingen. Basiscompetenties Palliatieve zorg voor verzorgenden en verpleegkundigen. Onderwijs en Gezondheidszorg 2019;4:26-9
Datla S, Verberkt C.A., Hoye, A., Janssen, D.J.A., and Johnson M.J. Palliat Med. Multi-disciplinary palliative care is effective in people with symptomatic heart failure: a systematic review and narrative synthesis. 2019. 33(8): 1003-16.
Goërtz Y.M.J., Spruit, M.A., Van ‘t Hul, A.J., Peters, J.B., Van Herck, M., Nakken, N., Djamin, R.S., Burtin, C., Thong, M.S.Y., Coors, A., Meertens-Kerris, Y., Wouters, E.F.M., Prins, J.B., Franssen, F.M.E., Muris, J.W.M., Vanfleteren, L.E.G.W., Sprangers, M.A.G. Janssen, D.J.A. and Vercoulen, J.H. Fatigue is highly prevalent in patients with COPD and correlates poorly with the degree of airflow limitation. Ther Adv Respir Dis. 2019. 13. 1-13.
Houben C.H.M., Spruit, M.A., Luyten, H., Pennings, H.-J., van den Boogaart, V.E.M., Creemers, J.P.H.M., Wesseling, G., Wouters, E.F.M., and Janssen, D.J.A. A cluster-randomized trial of a nurse-led advance care planning session in patients with COPD and their loved ones. Thorax. 2019. 74 (4):328-36.
Janssen, D.J.A., van den Beuken-van Everdingen, M.H.J., Verberkt, C.A., Creemers, J.P.H.M., Wouters, E.F.M. Fentanyl nasal spray in a patient with end-stage COPD and severe chronic breathlessness. Breathe.2019 15 (3) e122-e125.
Janssen D.J.A., Rechberger, S., Wouters, E.F.M, Schols, J.M.G.A., Johnson, M.J., Currow, D.C., Curtis, J.R. and Spruit, M.A. Clustering of 27,525,663 Death Records from the United States Based on Health Conditions Associated with Death: An Example of big Health Data Exploration. J. Clin. Med. 2019, 8, 922.
Janssen, D.J.A., Boyne, J., Currow, D.C., Schols, J.M.G.A., Johnson, M.J., Brunner-La Rocca, H.-P. Timely recognition of palliative care needs of patients with advanced chronic heart failure: a pilot study of a Dutch translation of the Needs Assessment Tool: Progressive Disease – Heart Failure (NAT:PD-HF). Eur J Cardiovasc Nurs. 2019. 18(5):375-88.
Janssen Daisy, Marieke van den Beuken-van Everdingen, Cornelia Verberkt, Jacques Creemers, Emiel Wouters. Excess use of fentanyl nasal spray in a patient with end stage COPD and severe chronic breathlessness: lessons learned. Breathe 2019;15:e122–e125
Johnson M.J. and Janssen D.J.A. Advance care planning – a “hard” skill for cardiology clinicians? Heart. 2019. 105 (17):1298-99.Klekamp Lisanne M., prof. dr. Marieke H.J. van den Beuken-van Everdingen, dr. Ann Hoeben, dr. Daisy J.A Janssen. Subcutane toediening van levetiracetam ter preventie van insulten in de stervensfase, een case report. Nederlands Vlaams Tijdschrift voor Palliatieve Zorg, 2019;16(2):60-4
Nakken N., Spruit, M.A., van den Bogaart, E.H.A., Crutzen, R., Muris, J.W., Wouters, E.F.M., Janssen, D.J.A. Identifying causes of perceptual differences in problematic activities of daily life between patients with COPD and proxies: a qualitative study. Aust Occup Ther J. 2019. 66.44-51.
Pieters Jolien, Diana H.J.M. Dolmans, Daniëlle M.L. Verstegen, Franca Warmenhoven, Annemie M. Courtens, Marieke H.J. van den Beuken-van Everdingen. Palliative care education in the undergraduate medical curricula: Students' views on the importance of, their confidence in, and knowledge of palliative care. BMC Palliative Care 12/2019;18(72))
Spruit, M.A., Rochester, C.L., Pitta, F., Kenn, K., Schols, A.M.W.J., Hart, N. Wouters, E.F.M., Nava, S., Dreher, M., Janssen, D.J.A., Johnson, M.J., Curtis, J.R., Sastry, M., and Franssen F.M.E. Pulmonary Rehabilitation, Physical Activity, Respiratory Failure, and Palliative Respiratory Care. Thorax. 2019. 74(7):693-99.
Theunissen Maurice, Mark Martens, Daisy J.A. Janssen, PhD, Jos M.G.A. Schols, PhD, Marieke H.J. van den Beuken-van Everdingen"Premature ending of a medication study in dying patients: lessons learned", research letter. J Pain Sympt Manage 2019;58(5): e4-e7
Voss, H., A. Vogel, A. M. A. Wagemans, A. L. Francke J. F. M. Metsemakers, A. M. Courtens, A. J. E. deVeer Advance care planning in the palliative phase of people with intellectual disabilities: analysis of medical files and interviews. Journal of Intellectual Disability Research 2019, volume 63 issue 10, 1262-1272
2018
Carmen H.M. Houben, Martijn A. Spruit, Hans Luyten, Herman Jan Pennings, Vivian E.M. Van Den Boogaart, Jacques P.H.M. Creemers, Geertjan Wesseling, Emiel F.M. Wouters, Daisy J.A. Janssen. Cluster-randomised trial of a nurse-led advance care planning session in patients with COPD and their loved ones. Thorax. https://doi.org/10.1136/thoraxjnl-2018-211943
Martens MJM, Janssen DJA, Schols JMGA, Beuken van den - Everdingen van MHJ. Opioid Prescribing Behavior in Long-Term Geriatric Care in the Netherlands. JAMDA. 2018;(11):974-80
Beuken van den-van Everdingen, M.H.J., van Kuijk, S.M.J., Janssen D.J.A., and Joosten, E.A.J. Treatment of pain in cancer: towards personalised medicine. Cancers. 2018. 10 (12). 10(502) (IF 5.326)
J. Haumann, S.M.J. van Kuijk, E. A. Joosten, M.H.J. van den Beuken-van Everdingen. The association between patient characteristics and opioid treatment response in neuropathic and nociceptive pain due to cancer. Journal of Palliative Medicine 2018; (IF 2.490)
Cindy A. Verberkt, Marieke H.J. van den Beuken-van Everdingen, Jos M.G.A. Schols, Sushma Datla, Carmen D. Dirksen, Miriam J. Johnson, Sander M.J. van Kuijk, Emiel F.M. Wouters, Daisy J.A. Janssen. Adverse respiratory effects of opioids for chronic breathlessness: to what extend can we learn lessons from chronic pain? Eur Respir J 2018;52(1):1800882 (IF 12.242)
Johan Haumann, Sander M.J. van Kuijk, José W. Geurts, Frank J.P. Hoebers, Bernd Kremer, Elbert A. Joosten, Marieke H.J. van den Beuken-van Everdingen. Methadone versus Fentanyl in Patients with Radiation Induced Nociceptive Pain with Head and Neck Cancer, a randomized controlled non-inferiority trial. Pain Practice 2018;18(3):331-40 (IF 2.495)
Robert Janknegt, Marieke van den Beuken – van Everdingen, Sjouke Schiere, Michael Überall, Roger Knaggs, Jaquie Hanley, Morten Thronaes. Rapid acting fentanyl formulations in breakthrough pain in cancer. Drug selection by means of the System of Objectified Judgement Analysis. Eur J Hosp Pharm 2018;25:e2 (IF 0.538)
Vaes, A.W., Delbressine, J.M.L., Mesquita, R., Goertz, Y.M.J., Janssen, D.J.A. Nakken, N., Franssen, F.M.E., Vanfleteren, L.E.G.W., Wouters, E.F.M. and Spruit M.A. The impact of pulmonary rehabilitation on activities of daily living in patients with COPD. J Appl Physiol. 2018. Published online ahead of print.
Van Herck, M., Spruit, M.A., Burtin, C., Djamin, R., Antons, J., Goertz, Y.M.J., Ebadi, Z., Janssen, D.J.A., Vercoulen, J.H., Peters, J.B., Thong, M.S.Y., Prins, J.B., Otker, J., Coors, A., Sprangers, M.A.G., Muris, J.W.M., Wouters, E.F.M., and van ’t Hul, A. Fatigue is highly prevalent in patients with asthma and contributes to the burden of disease. J Clin Med. 2018. 7(12):471.
van Beers, M., Janssen, D.J.A., Gosker, H.R., and Schols A.M.W.J. Cognitive impairment in COPD: disease burden, determinants and possible future interventions. Exp Rev Resp Med. 2018. 1-14.
Houben-Wilke, S., Janssen, D.J.A., Franssen, F.M.E., Vanfleteren, L.E.G.W., Wouters E.F.M., and Spruit, M.A. Contribution of individual COPD Assessment Test (CAT) items to CAT total score and effects of pulmonary rehabilitation on CAT scores. Health Qual Life Outcomes. 2018. 16(1):205.
Nakken, N., Spruit, M.A., van den Bogaart, E.H.A., Crutzen, R., Muris, J.W., Wouters, E.F.M., Janssen, D.J.A. Identifying causes of perceptual differences in problematic activities of daily life between patients with COPD and proxies: a qualitative study. Aust Occup Ther J. 2018.
Goërtz, Y.M.J., Looijmans, M., Prins, J.B., Janssen, D.J.A., Thong, M.S.Y.,Peters, J.B., Burtin, C., Meertens-Kerris, Y., Coors, A., Muris, J.W.M., Sprangers, M.A.G., Wouters, E.F.M., Vercoulen, J.H., and Spruit M.A. Fatigue in patients with Chronic Obstructive Pulmonary Disease: protocol of the longitudinal, observational FAntasTIGUE study. BMJ Open. 2018;8:e021745.
Janssen, D.J.A., Johnson, M.J., Spruit M.A. Palliative care needs assessment in chronic heart failure. Curr Opin Support Palliat Care. 2018. 12:25-31.
Jabbarian, L.J., Zwakman M., van der Heide, A., Kars M.C., Janssen, D.J.A., van Delden, J.J.M., Rietjens, J.A.C., Korfage I.J. Advance care planning in chronic respiratory diseases: a systematic review of preferences and practices. Thorax. 2018. 73(3):222-230.
Cleutjens, F.A.H.M., Spruit, M.A., Ponds, R.W.H.M., Vanfleteren, L.E.G.W., Franssen, F.M.E., Gijsen C., Dijkstra, J.B., Wouters, E.F.M., and Janssen D.J.A. Cognitive impairment and clinical characteristics in patients with COPD. Chron Resp Dis. 2018.15(2):91-102.
M.P.H. Bischoff, prof. dr. M.H.J. van den Beuken-Everdingen, prof. dr. A-M.C. Dingemans. Effect of early and systematic integration of palliative care in patients with advanced cancer: a randomised controlled trial. van Butsele et all. NTvO 2018;15(6):236-7 Susanto C, Kooman J, Courtens AM, Konings CJAM. Conservative care as a treatment option for patients aged 75 years and older with CKD stage V: a National survey in the Netherlands.Eur Geriatr Med. 2018;9(2):235-242. doi: 10.1007/s41999-018-0031-9. Epub 2018 Feb 12
2017
Rietjens JAC, Sudore RL, Connolly M, van Delden JJ, Drickamer MA, Droger M, van der Heide A, Heyland DK, Houttekier D, Janssen DJA, Orsi L, Payne S, Seymour J, Jox RJ, Korfage IJ, on behalf of the European Association for Palliative Care. Definition and recommendations for advance care planning: an international consensus supported by the European Association for Palliative Care. Lancet Oncol. 2017;18:e543-512016
J. Haumann, J.W Geurts, S.M.J. van Kuijk, B. Kremer, E.A. Joosten, M.H.J. van den Beuken-van Everdingen. Methadone is superior to fentanyl in treating neuropathic pain in patients with head-and-neck cancer. Eur J Cancer. 2016;65:121-129Hochstenbach LM, Zwakhalen SM, Courtens AM, van Kleef M, de Witte LP. Feasibility of a mobile and web-based intervention to support self-management in outpatients with cancer pain. Eur J Oncol Nurs. 2016;23:97-105
Van den Heuvel LA, Spruit MA, Schols JM, Hoving C, Wouters EF, Janssen DJ. Barriers and facilitators to end-of-life communication in advanced chronic organ failure. Int J Palliat Nurs. 2016;22(5):222-9
C.A. Verberkt, M.H.J. van den Beuken-van Everdingen, F.M.E. Franssen, C.D. Dirksen, J.M.G.A. Schols, E.F.M. Wouters, D.J.A. Janssen. A randomized controlled trial on the benefits and respiratory adverse effects of morphine on refractory dyspnea in patients with COPD: protocol of the MORDYC study. Contemporary Clinical Trials. 2016;47:228-34
Marieke H.J. van den Beuken-van Everdingen, MD, PhD, Laura M.J. Hochstenbach, MSc, Bert E.A.J. Joosten, PhD, Vivianne C.G. Tjan-Heijnen, MD, PhD, Daisy J.A. Janssen, MD, PhD. Update on prevalence of pain in patients with cancer: Systematic review and meta-analysis. J Pain Symptom Management. 2016;51(6):1070-90
Marieke HJ van den Beuken-van Everdingen, MD, PhD, Alexander de Graeff, MD, PhD,Joost LM Jongen, MD, PhD,Denise Dijkstra, MsC, Irina Mostovaya, MD, PhD, Kris C Vissers, MD, PhD, on behalf of the working group national guideline “Diagnosis and treatment of cancer pain”. Pharmacological treatment of pain in cancer patients: the role of adjuvant analgesics, a systematic review. Pain Practice. 2016
Hendriks LE, Hermans BCM, van den Beuken-van Everdingen MHJ, Hochstenbag MM, Dingemans A-M. Effect of bisphosphonates, denosumab and radioisotopes on bone pain and quality of life in non-small cell lung cancer patients with bone metastases: a systematic review. Journal of Thoracic Oncology. 2016;11(2):155-73
2015
Wagemans AMA, van Schrojenstein Lantman-de Valk HMJ, Proot IM, Metsemakers J, Tuffrey-Wijne I, Curfs LMG. End-of-Life Decision-Making for People With Intellectual Disability From the Perspective of Nurses. Journal of Policy and Practice in Intellectual Disabilities. 2015;12(4):294-302G. (Art) Vreugdenhil en M.H.J. (Marieke) van den Beuken-van Everdingen. Starten en stoppen met palliatieve tumorbehandeling, Overwegingen in het kader van kwaliteit van leven en kosten. Nederlands Tijdschrift voor Geneeskunde. 2015;159:A8729
Loes M.T. Hoogveld, Dennis C.J.J. Bergmans, Sergej de Vries, Huub van Proemeren, Marieke H.J. van den Beuken-van Everdingen, Jan G. Zijlstra, Walther N.K.A. van Mook IC-patiënten die thuis willen overlijden. Hoe kun je deze laatste wens vervullen? Nederlands Tijdschrift voor Geneeskunde. 2015;159: A8711:1-5
Daisy J.A. Janssen, Marieke H.J. van den Beuken-van Everdingen en Jos M.G.A. Schols Verrast door de ‘surprise question’ Nederlands Tijdschrift voor Geneeskunde. 2015;159(17):730-3
Hochstenbach LMJ, Courtens AM, Zwakhalen SMG, Kleef van M, Witte de LP. Self-management support intervention to control cancer pain in the outpatient setting: a randomized controlled trial study protocol. BMC Cancer. 2015;416(15). doi:10.1186/s12885-015-1428-1
Magdelijns FJH, Beuken van den-Everdingen van MHJ, Courtens AM, Janssen DJA. Behandeling van doorbraakpijn bij kanker. Ned Tijdschr Geneeskd. 2015;159:A8121
2014
Wagemans AMA, Wijmen FCB. Advance care planning: Proactief medisch beleid bij mensen met een verstandelijke beperking.Ned Tijschr Geneeskd. 2014; 158:A8433Vermeulen J, Verwey R, Hochstenbach LMJ, Weegen van der S, Man YP, Witte de LP. Experiences of multidisciplinary development team members during user-centered design of telecare products and services: A qualitative study. Journal of Medical Internet Research. 2014;16(5):e124.
Janssen DJA, McCormick JR. Palliative care and pulmonary rehabilitation. Clin Chest Med. 2014. doi:10.1016/j.ccm.2014.02.006
Houben CH, Spruit MA, Groenen M., Wouters EFM, Janssen DJA. Efficacy of Advance Care Planning: A systematic review and meta-analysis. J Am Med Dir Assoc. doi.org/10.1016/j.jamda.2014.01.008
2013
Houben CHM, Spruit MA, Wouters EFM, et al. A randomised controlled trial on the efficacy of advance care planning on the quality of end-of-life care and communication in patients with COPD: the research protocol. BMJ Open. 2014;4:e004465. doi:10.1136/bmjopen-2013-00446Beuken van den-Everdingen van MHJ, Geurts JW, Patijn J. Prolonged QT interval by methadone: Relevance for daily practice? A prospective study in patients with cancer and noncancer pain. J Opioid Manag. 2013;9(4): 263-267